Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure.

To test the hypothesis that local vascular production of angiotensin II is necessary for the normal regulation of blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotensin-converting enzyme (ACE). This was accomplished using a novel strategy of targeted homologous recombination to separate the transcriptional control of somatic ACE from its endogenou...

Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II.

Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE on the surface of hepatocytes. ACE 1/3 mice express no endothelial ACE and lack ACE within the lung...

Angiotensin Converting Enzyme in Sarcoidosis

Effects of angiotensin-converting enzyme inhibitors on central blood pressure.

Effects of Angiotensin-Converting Enzyme Inhibitors on Central Blood Pressure To the Editor: From a substudy of the Australian National Blood Pressure 2 (ANBP2) trial, Dart et al1 concluded that there was no evidence for a disproportionate lowering of central systolic pressure to explain the favorable effects of an angiotensin-converting enzyme inhibitor over diuretic in the main ANBP2 study. R...

angiotensin converting enzyme in sarcoidosis

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